Evidence review · Published July 22, 2026 · Sources checked July 22, 2026

5-Amino-1MQ research overview

5-Amino-1MQ is an experimental small molecule—not a peptide—studied as an inhibitor of nicotinamide N-methyltransferase (NNMT).

Evidence boundary: published research does not establish the identity or performance of a separately supplied batch. The catalog product is supplied only for qualified in vitro laboratory research and is not for human or animal use.

What is 5-Amino-1MQ?

Published work has examined NNMT inhibition in biochemical systems, cultured cells, and mouse models, including high-fat-diet and muscle-injury experiments.

Research category
Metabolic & energy research
Study models represented
Biochemical assays, cultured cells, mice, and rat pharmacokinetics
Names in the literature
5-amino-1-methylquinolinium; NNMT inhibitor
Primary boundary
No cited study establishes a therapeutic effect or general human-use profile.

What does the selected evidence support?

The selected literature is preclinical. Rat bioanalytical work characterizes plasma measurement and pharmacokinetics but does not establish clinical safety or effectiveness.

Primary sources

  1. Neelakantan et al., Scientific Reports (2017) — NNMT inhibition and metabolic observations in high-fat-diet mouse models. DOI: 10.1038/s41598-017-15850-7
  2. Neelakantan et al., Biochemical Pharmacology (2019) — C2C12 cell and mouse muscle-injury experiments. DOI: 10.1016/j.bcp.2019.02.008
  3. Awosemo et al., Journal of Pharmaceutical and Biomedical Analysis (2021) — LC-MS/MS method and pharmacokinetic measurements in rat plasma. DOI: 10.1016/j.jpba.2021.114255

Research literature and product documentation are different

A publication describes a study and its results. A batch-specific Certificate of Analysis documents characteristics of a supplied research material. One does not substitute for the other.

Review 5-Amino-1MQ product specifications · Browse the COA library · Read the research-use policy

Prepared by The Pep Labs Research Editorial Team. This evidence summary is not medical advice and contains no dosing or administration guidance.